depending on what kind of material you save with Melodyne, the file size can grow drastically. On a 32-bit system, saving such a large file will take much longer than on a 64-bit system. Even if you have plenty of RAM, a 32-bit system can't benefit from it as much as a 64-bit system can. Please see our 64-bit video
for more details.
Furthermore, a project file of 36 MB size seems to be huge for Nuendo. What else is going on in that project? What if you start with an empty Nuendo project, insert Melodyne and transfer one audio file only. Does it also crash? If it doesn't, the issue is clearly related to memory.
I'll pass this on to our R&D guys. Meanwhile, could you run a test for us with Nuendo in 64-bit and see if it makes a difference? Have you also tried the RAM saving tips I suggested above? Another thing you could try is to reassign the storage location for the Melodyne audio cache in the Melodyne preferences to a different folder or partition.