I am the current developer and maintainer of a driver called wineasio http://sourceforge.net/projects/wineasio/
that provides an ASIO interface to windows programs running under wine.
The last few years I've been repeatedly asked about how to run Melodyne under linux, but I've never managed to get it working. I tried again the other day, with Melodyne Editor 2.1.0 Trial, and to my surprise it appears to work more or less perfectly. I have ran the standalone version with the wineasio driver at 64 samples latency, and I've also run the vst plugin hosted by reaper at 64 samples latency.
Hardware used is an i7-2600k cpu with the builtin hd3000 gpu on a z68 mainboard and rme multiface soundcard. Software 64 bit Archlinux with 32bit wine 1.5.10. Melodyne installation was straightforward, but in order to run the program properly I needed to install gdiplus via the winetricks script.
The only problems I've seen so far, has been some minor drawing problems when resizing the vst plugin, and it appeears that if you load the plugin, then remove it, and then load it again, it fails to connect to the internet and falls back to expired demo mode.
I realize that for most this is just a novelty, but I wanted to post the positive news for the people that have previously inquired about it.